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Enhancement of baicalin by hexamethylene bisacetamide on the induction of apoptosis contributes to simultaneous activation of the intrinsic and extrinsic apoptotic pathways in human leukemia cells.

Abstract
Hexamethylene bisacetamide (HMBA) and natural flavanoid baicalin both exert potent antileukemic activity. However, there is currently no data on the anti-leukemic effects of baicalin in combination with HMBA. In the present study, we demonstrated that the combination of baicalin and HMBA synergistically inhibited the proliferation of acute myeloid leukemia (AML) cell lines. In addition, a slight G0/G1 phase arrest and significant apoptosis were observed. The combination treatment triggered apoptosis through the intrinsic pathway, which involved loss of MMP, decreased Bcl‑2/Bax ratio and Bcl‑XL/Bax ratio, caspase‑9 activation, as well as through the extrinsic pathway mediated by Fas and caspase‑8 activation. On the other hand, combination of baicalin and HMBA showed little toxic effect on peripheral blood mononuclear cells from healthy volunteers. Our results raise the possibility that the novel combination of baicalin and HMBA may be a promising regimen for the treatment of AML.
AuthorsXia Ren, Yubao Zhang, Cuiling Li, Hengxiao Wang, Zheng Jiang, Zhiyong Zhang, Qiang Guo, Guanhua Song, Kehong Bi, Guosheng Jiang
JournalOncology reports (Oncol Rep) Vol. 30 Issue 5 Pg. 2071-80 (Nov 2013) ISSN: 1791-2431 [Electronic] Greece
PMID23970138 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetamides
  • Flavonoids
  • bcl-2-Associated X Protein
  • baicalin
  • Caspase 8
  • Caspase 9
  • hexamethylene bisacetamide
Topics
  • Acetamides (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Apoptosis (drug effects)
  • Caspase 8 (metabolism)
  • Caspase 9 (metabolism)
  • Cell Line, Tumor
  • Flavonoids (administration & dosage)
  • G1 Phase (drug effects)
  • Healthy Volunteers
  • Humans
  • Leukemia, Myeloid, Acute (drug therapy, genetics, pathology)
  • Leukocytes, Mononuclear (drug effects)
  • bcl-2-Associated X Protein (genetics, metabolism)

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