Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: a randomized, open-label pilot study.

Abstract

AIM:

The aim of the study was to evaluate the effect of mouth cleaning with hinokitiol-containing gel on oral malodor.

METHODS:

An open-label, randomized, controlled trial was conducted to assess oral malodor and clinical parameters related to oral malodor before and after mouth cleaning with hinokitiol-containing gel (n = 9) or with gel not including hinokitiol (n = 9). Mouth cleaning included the teeth, gingiva, and tongue and was carried out 3 times per day for 4 weeks.

RESULTS:

Organoleptic test (OLT) scores (P = .021), levels of hydrogen sulfide (P = .008) and methyl mercaptan (P = .020), frequency of bleeding on probing, average probing pocket depth, and plaque index significantly improved in the group using hinokitiol. In contrast, only the OLT score (P = .031) significantly improved in the control group after the treatment regimen.

CONCLUSION:

Mouth cleaning with hinokitiol-containing gel may be effective for reduction of oral malodor.

• Authors: Kosaku Iha, Nao Suzuki, Masahiro Yoneda, Toru Takeshita, Takao Hirofuji
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 116 Issue 4 Pg. 433-9 (Oct 2013) ISSN: 2212-4411 [Electronic] United States
• PMID: 23969334 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Infective Agents
• Monoterpenes
• Plant Oils
• Toothpastes
• Tropolone
• Cetylpyridinium
• beta-thujaplicin

Topics

• Adult
• Aged
• Anti-Infective Agents (therapeutic use)
• Candida albicans (isolation & purification)
• Cetylpyridinium (therapeutic use)
• Chromatography, Gas
• Cupressaceae
• Dental Plaque Index
• Female
• Halitosis (drug therapy, microbiology)
• Humans
• Male
• Middle Aged
• Monoterpenes (therapeutic use)
• Mouth (microbiology, pathology)
• Phytotherapy
• Pilot Projects
• Plant Oils (therapeutic use)
• Saliva (microbiology)
• Toothbrushing
• Toothpastes (pharmacology)
• Tropolone (analogs & derivatives, therapeutic use)