Abstract | CONTEXT: OBJECTIVE: The aim was to study long-term predictors for TART development in a retrospective longitudinal study. DESIGN: Fifty men with classic 21-hydroxylase deficiency (31 salt wasting, 19 simple virilizing) were investigated. Testicular ultrasound at a median age at investigation of 27 years detected TARTs in 28 of 50 subjects (19 salt wasting, 9 simple virilizing). TART presence was correlated with long-term parameters of disease control during childhood and adolescence obtained from patients' charts: 24-hour urine pregnanetriol, serum 17-hydroxyprogesterone, onset and stage of pubic hair development, testicular growth, and bone age in relation to chronological age. RESULTS: There was no difference in pregnanetriol excretion over lifetime between patients with and without TARTs. Similarly, neither development of pubic hair and testicular volume (Tanner) nor bone age in relation to chronological age differed between the two groups. Furthermore, the two groups had the same body mass index and the same impairment of final height in relation to midparental target height. CONCLUSION: Our longitudinal analysis demonstrates no association between TART presence and parameters of disease control. These data, therefore, argue for other mechanisms more relevant for TART induction including those occurring during fetal development.
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Authors | Nicole Reisch, Marietta Rottenkolber, Anais Greifenstein, Nils Krone, Heinrich Schmidt, Martin Reincke, Hans-Peter Schwarz, Felix Beuschlein |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 11
Pg. E1820-6
(Nov 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 23969190
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Pregnanetriol
- 17-alpha-Hydroxyprogesterone
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Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adrenal Hyperplasia, Congenital
(blood, complications, drug therapy)
- Adrenal Rest Tumor
(blood, diagnostic imaging, etiology)
- Adult
- Child
- Child, Preschool
- Cross-Sectional Studies
- Follow-Up Studies
- Glucocorticoids
(therapeutic use)
- Humans
- Infant
- Infertility, Male
(etiology)
- Longitudinal Studies
- Male
- Pregnanetriol
(blood)
- Retrospective Studies
- Testicular Neoplasms
(blood, diagnostic imaging, etiology)
- Ultrasonography
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