Studies on cell-mediated immune response to rabies virus immunization in dogs.

Abstract

Peripheral blood leucocytes (PBL) from unvaccinated dogs and dogs vaccinated subcutaneously with beta-propiolactone (BPL) inactivated sheep brain antirabies vaccine were exposed in vitro to rabies antigen. A direct leucocyte migration inhibition (LMI) assay in agarose was used to study the cell-mediated immune (CMI) response. The CMI response could be detected as early as 7 days postvaccination. It reached a peak by 14 days postvaccination followed by a decline. The PBL from unvaccinated control dogs were not stimulated by rabies virus antigen.

• Authors: R Jayakumar, P Ramadass
• Journal: Vaccine (Vaccine) Vol. 8 Issue 4 Pg. 304-5 (Aug 1990) ISSN: 0264-410X [Print] Netherlands
• PMID: 2396468 (Publication Type: Journal Article)

Chemical References

• Antigens, Viral
• Rabies Vaccines

Topics

• Animals
• Antigens, Viral (immunology)
• Dogs
• Immunity, Cellular (physiology)
• Immunization Schedule
• Rabies (prevention & control)
• Rabies Vaccines (immunology, therapeutic use)
• Rabies virus (immunology)
• Sheep
• Vaccination