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MicroRNA expression patterns related to merkel cell polyomavirus infection in human merkel cell carcinoma.

Abstract
Merkel cell carcinoma (MCC) is an aggressive and lethal type of neuroendocrine skin cancer. Mutated Merkel cell polyomavirus (MCV) is commonly found in MCC, and leads to upregulation of the survivin oncogene. However, ∼20% of MCC tumors do not have detectable MCV, suggesting alternative etiologies for this tumor type. In this study, our aim was to evaluate microRNA (miRNA) expression profiles and their associations with MCV status and clinical outcomes in MCC. We showed that miRNA expression profiles were distinct between MCV-positive (MCV+) and MCV-negative (MCV-) MCCs and further validated that miR-203, miR-30a-3p, miR-769-5p, miR-34a, miR-30a-5p, and miR-375 were significantly different. We also identified a subset of miRNAs associated with tumor metastasis and MCC-specific survival. Functionally, overexpression of miR-203 was found to inhibit cell growth, induce cell cycle arrest, and regulate survivin expression in MCV- MCC cells, but not in MCV+ MCC cells. Our findings reveal a mechanism of survivin expression regulation in MCC cells, and provide insights into the role of miRNAs in MCC tumorigenesis.
AuthorsHong Xie, Linkiat Lee, Stefano Caramuta, Anders Höög, Nanna Browaldh, Viveca Björnhagen, Catharina Larsson, Weng-Onn Lui
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 134 Issue 2 Pg. 507-517 (Feb 2014) ISSN: 1523-1747 [Electronic] United States
PMID23962809 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • MicroRNAs
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Merkel Cell (genetics, secondary, virology)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Merkel cell polyomavirus (genetics)
  • MicroRNAs (genetics)
  • Middle Aged
  • Polyomavirus Infections (genetics)
  • Skin Neoplasms (genetics, pathology, virology)
  • Transcriptome
  • Tumor Virus Infections (genetics)
  • Young Adult

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