Rubrolide R: a new furanone metabolite from the ascidian Synoicum of the Indian Ocean.

Abstract

A new furanone metabolite of the rubrolide family, rubrolide R as diacetate (1), was isolated from a new species of the ascidian Synoicum, besides the known compounds rubrolide A (as diacetate), cadiolide B and prunolide A. The structure of the new rubrolide was elucidated by a study of spectral data. The crude extract and isolated compounds (prunolide A and cadiolide B) showed antiviral activity against the Japanese encephalitis virus. Prunolide A showed cytotoxic activity against breast cancer cell lines at a concentration of < 1 μM.

• Authors: Desaraju Smitha, Muthyala Murali Krishna Kumar, Hechhu Ramana, Desaraju Venkata Rao
• Journal: Natural product research (Nat Prod Res) Vol. 28 Issue 1 Pg. 12-7 ( 2014) ISSN: 1478-6427 [Electronic] England
• PMID: 23962161 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Antiviral Agents
• Furans
• rubrolide R

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Antiviral Agents (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Encephalitis Virus, Japanese (drug effects)
• Female
• Furans (chemistry, isolation & purification, pharmacology)
• Humans
• Indian Ocean
• Molecular Structure
• Urochordata (chemistry)