Abstract | OBJECTIVE: STUDY DESIGN: Prospective, randomized controlled trial. Settings Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey. SUBJECT AND METHODS: Seventy-nine patients who met the inclusion criteria for idiopathic sudden sensorineural hearing loss were included in this study. Patients were randomly divided into 2 groups according to treatment: group A received combination therapy (intratympanic methylprednisolone + oral steroid) and group B received oral steroid alone. Of the 79 patients included, 6 patients missed the 1-month follow-up visit. Overall, 73 patients (37 combination group, 36 oral steroid group) who completed the 1-month follow-up and study intervention were included in the per-protocol analysis. Both the relationship between certain prognostic factors and the clinical outcome after treatment were analyzed. RESULTS: Combination therapy showed significant hearing improvement and speech discrimination scores compared with the use of systemic steroids alone (P < .05). In hearing outcomes in patients with severe hearing loss, combination therapy had statistically significant hearing improvement compared with oral steroid alone (P < .05). CONCLUSION: We recommend that combination therapy can be considered as initial treatment especially for patients with severe hearing loss.
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Authors | Onur Gundogan, Ercan Pinar, Abdulkadir Imre, Sedat Ozturkcan, Ozge Cokmez, Ali Cihan Yigiter |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 149
Issue 5
Pg. 753-8
(Nov 2013)
ISSN: 1097-6817 [Electronic] England |
PMID | 23959817
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glucocorticoids
- Dexamethasone
- Methylprednisolone
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Topics |
- Administration, Oral
- Audiometry, Pure-Tone
- Dexamethasone
(administration & dosage)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glucocorticoids
(administration & dosage)
- Hearing
- Hearing Loss, Sudden
(diagnosis, drug therapy)
- Humans
- Injections
- Male
- Methylprednisolone
(administration & dosage)
- Middle Aged
- Prospective Studies
- Treatment Outcome
- Tympanic Membrane
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