Abstract | BACKGROUND AND PURPOSE: MATERIAL AND METHODS: The impact of AR and 11 additional factors on locoregional control (LRC), metastases-free survival (MFS), and overall survival (OS) was retrospectively studied in 163 patients with nonmetastatic stage III/IV SCCHN. Additional factors included age, gender, ECOG performance status, pre- radiotherapy (pre-RT) hemoglobin levels, tumor site, histologic grade, T category, N category, HPV status, extent of resection, and concurrent chemotherapy. RESULTS: On multivariate analysis, improved LRC was significantly associated with pre-RT hemoglobin levels≥12 g/dl (risk ratio [RR] 2.22; 95% confidence interval [CI] 1.19–4.13; p=0.013), tumor site (RR 1.39; 95% CI 1.14–1.70; p=0.001), lower T category (RR 1.67; 95% CI 1.18–2.44; p=0.003), and lower N category (RR 4.18; 95% CI 1.90–10.55; p<0.001). Improved MFS was associated with AR expression (RR 2.21; 95% CI 1.01–5.41; p=0.048), better ECOG performance status (RR 3.19; 95% CI 1.50–7.14; p=0.003), lower T category (RR 2.24; 95% CI 1.47–3.65; p<0.001), and lower N category (RR 5.33; 95% CI 2.07–16.63; p<0.001). OS was positively associated with AR expression (RR 1.99; 95% CI 1.06–4.00; p=0.032), better ECOG performance status (RR 2.20; 95% CI 1.20–4.09; p=0.010), pre-RT hemoglobin levels≥12 g/dl (RR 2.13; 95% CI 1.19–3.82; p=0.012), lower T category (RR 1.81; 95% CI 1.30–2.62; p<0.001), and lower N category (RR 3.41; 95% CI: 1.65–7.80; p<0.001). CONCLUSION:
Tumor cell expression of AR was an independent prognostic factor for MFS and OS and should be considered in future prospective trials.
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Authors | D Rades, N D Seibold, S E Schild, K L Bruchhage, M P Gebhard, F Noack |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 189
Issue 10
Pg. 849-55
(Oct 2013)
ISSN: 1439-099X [Electronic] Germany |
PMID | 23959264
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Receptors, Androgen
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Carcinoma, Squamous Cell
(chemistry, mortality, pathology)
- Female
- Germany
(epidemiology)
- Head and Neck Neoplasms
(chemistry, mortality, pathology)
- Humans
- Incidence
- Male
- Middle Aged
- Neoplasm Invasiveness
- Prognosis
- Receptors, Androgen
(analysis)
- Reproducibility of Results
- Risk Assessment
- Sensitivity and Specificity
- Squamous Cell Carcinoma of Head and Neck
- Survival Rate
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