Abstract | BACKGROUND: METHODS: One hundred non diabetic Saudi females were enrolled in this study. They were further divided according to their body mass index (BMI) into two groups. Group I, 46 non diabetic subjects with normal body weight and group II, 54 overweight and obese females. Adiponectin 45T/G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum adiponectin was measured by ELISA. RESULTS: Obese women exhibited a higher distribution of TG/GG genotype compared with non-obese women. SNP +45T>G genotypes were associated with higher FBG, insulin levels and HOMA-IR with lower total adiponectin levels in obese Saudi women. Otherwise the all estimated variables revealed non-significant differences among the non-obese genotypes. The observed differences in insulin resistance markers were very significant among women with a higher body weight but not among normal body weight women, thus suggesting that SNP +45T>G effects on insulin sensitivity may depend upon body weight and body fat status. CONCLUSION:
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Authors | Amal Mohammed Husein Mackawy |
Journal | Gene
(Gene)
Vol. 530
Issue 1
Pg. 158-63
(Nov 01 2013)
ISSN: 1879-0038 [Electronic] Netherlands |
PMID | 23958652
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Adiponectin
- Blood Glucose
- Insulin
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Topics |
- Adiponectin
(genetics)
- Adult
- Blood Glucose
(genetics)
- Diabetes Mellitus, Type 2
(drug therapy, genetics, pathology)
- Female
- Genetic Association Studies
- Genotype
- Humans
- Insulin
(blood, genetics)
- Insulin Resistance
(genetics)
- Middle Aged
- Obesity
(blood, genetics, pathology)
- Polymorphism, Single Nucleotide
- Saudi Arabia
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