Role of casein phosphopeptide amorphous calcium phosphate in remineralization of white spot lesions and inhibition of Streptococcus mutans?

Abstract

INTRODUCTION:

To promote the remineralization by ionic exchange mechanism instead of invasive techniques many remineralizing agents can be used.

OBJECTIVE:

To evaluate the remineralization effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on white spot lesions (WSLs) and its inhibitory effect on Streptococcus mutans colonization.

MATERIALS AND METHODS:

The study group consisted of 60 subjects exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: A test group using CPP-ACP cream (GC-Tooth Mousse, Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-month. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva collection was repeated.

RESULT:

DIAGNOdent measurements were increased by time (P = 0.002) in the control group and no statistically significant difference (P = 0.217) was found in the test group by the 3-month period. In both groups, the mutans counts were decreased in the 3-month experimental period.

CONCLUSION:

These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however, longer observation is recommended to confirm whether the greater change in WSLs is maintained.

• Authors: Ruchi Vashisht, Rajamani Indira, S Ramachandran, Anil Kumar, Manali Ramakrishnan Srinivasan
• Journal: Journal of conservative dentistry : JCD (J Conserv Dent) Vol. 16 Issue 4 Pg. 342-6 (Jul 2013) ISSN: 0972-0707 [Print] India
• PMID: 23956538 (Publication Type: Journal Article, Retracted Publication)