Abstract | BACKGROUND: METHODS: We examined lymphoma occurrence in a nationwide cohort of 19,885 Danish women who underwent breast implant surgery during 1973-2010. Standardized incidence ratios (SIR), with 95% confidence intervals (CI), for ALCL and lymphoma overall associated with breast implantation were calculated. RESULTS: During 179,246 person-years of follow-up, we observed 31 cases of lymphoma among cohort members. No cases of ALCL were identified. SIRs for ALCL and lymphoma overall were zero (95% CI, 0-10.3) and 1.20 (95% CI, 0.82-1.70), respectively. CONCLUSIONS: In our nationwide cohort study, we did not find an increased risk of lymphoma in general, or ALCL in particular, among Danish women who underwent breast implantation. However, our evaluation of ALCL risk was limited by the rarity of the disease. IMPACT:
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Authors | Maja Ølholm Vase, Søren Friis, Andrea Bautz, Knud Bendix, Henrik Toft Sørensen, Francesco d'Amore |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 22
Issue 11
Pg. 2126-9
(Nov 2013)
ISSN: 1538-7755 [Electronic] United States |
PMID | 23956025
(Publication Type: Journal Article, Multicenter Study)
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Copyright | ©2013 AACR. |
Topics |
- Breast Implants
(adverse effects, statistics & numerical data)
- Case-Control Studies
- Cohort Studies
- Denmark
(epidemiology)
- Female
- Humans
- Incidence
- Lymphoma, Large-Cell, Anaplastic
(epidemiology, etiology, pathology)
- Risk Factors
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