[A case of simultaneously occurred amiodarone-induced hepatitis and hypothyroidism].

Abstract

Amiodarone is a di-iodated benzofuran derivative that is commonly used to treat patients with various cardiac arrhythmias. It is associated with side effects that involve the liver, thyroid, and other organs. Approximately 1-3% of patients treated with amiodarone suffer from symptomatic liver disease. Thyroid dysfunction occurs in 10% of patients treated with amiodarone. A 65-year-old woman with coronary heart disease and atrial fibrillation was administered with amiodarone. She developed nausea, vomiting, dyspepsia, and sweating within 9 months of amiodarone administration (200 mg orally once a day). Results of the laboratory finding showed increased hepatic enzymes, and low thyroid hormone levels. A liver biopsy showed irregular arrangement of hepatocytes and diffuse micro- and macrovesicular fatty changes. Electron microscopy findings showed pleomorphic mitochondria with crystalloid inclusions and membrane-bound lysosomal structures. The liver and thyroid functions returned to normal, after the amiodarone was stopped. We describe an unusual case in which amiodarone induced hepatitis and hypothyroidism simultaneously. Physicians should take a close look to the adverse event when using amiodarone which can cause adverse effects in multiple organs.

• Authors: Young Shim Cho, Joung Ho Han, Hee Bok Chae, Jae Su Kim, Ky Man Kang, Sang Min Park, Jun Cheol Lim
• Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (Korean J Gastroenterol) Vol. 62 Issue 1 Pg. 59-63 (Jul 2013) ISSN: 2233-6869 [Electronic] Korea (South)
• PMID: 23954962 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amiodarone

Topics

• Aged
• Amiodarone (adverse effects, therapeutic use)
• Arrhythmias, Cardiac (drug therapy)
• Chemical and Drug Induced Liver Injury (complications, diagnostic imaging, pathology)
• Female
• Fibrosis (pathology)
• Humans
• Hypothyroidism (chemically induced, complications)
• Microscopy, Electron
• Mitochondria (drug effects, metabolism)
• Tomography, X-Ray Computed
• Treatment Outcome