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A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma.

AbstractBACKGROUND:
Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels.
METHODS:
The most commonly identified and tested immunoglobulins are IgA, IgG and IgM.
RESULTS:
Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins.
CONCLUSION:
We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.
AuthorsJulie Chepovetsky, Ajai Chari, Sundar Jagannath, Lakshmi Ramanthan
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 425 Pg. 233-5 (Oct 21 2013) ISSN: 1873-3492 [Electronic] Netherlands
PMID23954772 (Publication Type: Case Reports, Journal Article)
Copyright© 2013.
Chemical References
  • Immunoglobulin A
  • Immunoglobulin D
  • Immunoglobulin lambda-Chains
Topics
  • Adult
  • Clone Cells
  • Delayed Diagnosis
  • Humans
  • Immunoglobulin A (blood)
  • Immunoglobulin Class Switching
  • Immunoglobulin D (blood)
  • Immunoglobulin lambda-Chains (blood)
  • Male
  • Multiple Myeloma (blood, diagnosis, immunology)

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