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Impaired secondary oxidant deactivation capacity and enhanced oxidative stress in serum from alveld affected lambs.

Abstract
Alveld is a hepatogenous photosensitivity disorder in lambs. The aim of the study was to investigate if alveld affected lambs had a reduced capacity to handle oxidative stress induced from either endogenous and/or exogenous photosensitizers. Serum samples from alveld lambs (n=33) were compared to serum samples from control lambs (n=31) and exposed to a controlled amount of singlet oxygen ((1)O2). The sera from alveld lambs were found to have an impaired ability to deactivate reactive oxygen species (ROS) compared to control sera. A higher degree of initial hemolysis and a higher concentration of the exogenous photosensitizer phytoporphyrin (PP) were detected in alveld sera compared to the controls. The action spectrum for the formation of (1)O2 indicated that PP as well as the endogenous compound protoporphyrin IX (PP IX) may act as in vivo photosensitizers. A relatively high level of iron was detected in pooled serum from alveld lambs that showed a high degree of hemolysis. It was concluded that alveld photosensitivity is likely to be initiated by a photodynamic reaction involving PP and possibly also PP IX followed by a light-independent reaction involving hemoglobin-related products and catalysis by the Fenton reaction.
AuthorsAnne Bee Hegge, Ivar Mysterud, Jan Karlsen, Olav M Skulberg, Carl M M Laane, Trond Schumacher, Hanne Hjorth Tønnesen
JournalJournal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 126 Pg. 126-34 (Sep 05 2013) ISSN: 1873-2682 [Electronic] Switzerland
PMID23954345 (Publication Type: Journal Article)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Minerals
  • Oxidants
  • Protoporphyrins
  • Singlet Oxygen
  • protoporphyrin IX
Topics
  • Animals
  • Hemolysis
  • Minerals (metabolism)
  • Oxidants (blood, metabolism)
  • Oxidative Stress
  • Photosensitivity Disorders (blood, immunology, metabolism, veterinary)
  • Protoporphyrins (metabolism)
  • Sheep
  • Sheep Diseases (blood, immunology, metabolism)
  • Singlet Oxygen (metabolism)

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