Abstract |
Ten eudesmane-type sesquiterpene derivatives (1-10), including six cuauhtemone derivatives (1-6), one di-norsesquiterpene (3-oxo-di-nor-eudesma-4-en-11-oic acid, 7), and three eudesmane glycosides (alatoside F-H, 8-10) were isolated from the whole plants of Laggera alata together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, acid hydrolysis, and compounds 1 and 7 were studied by single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the application of the modified Mosher's method. All of the isolated eudesmane-type sesquiterpenes were evaluated for their cytotoxic activities on six human cancer cell lines, but all of the compounds were inactive on the tested cell lines in the concentration of 100 μg/mL.
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Authors | Guo-Cai Wang, Guo-Qiang Li, Hua-Wei Geng, Tao Li, Jiao-Jiao Xu, Fang Ma, Xia Wu, Wen-Cai Ye, Yao-Lan Li |
Journal | Phytochemistry
(Phytochemistry)
Vol. 96
Pg. 201-7
(Dec 2013)
ISSN: 1873-3700 [Electronic] England |
PMID | 23954074
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents, Phytogenic
- Drugs, Chinese Herbal
- Glycosides
- Sesquiterpenes, Eudesmane
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, pharmacology)
- Asteraceae
(chemistry)
- Crystallography, X-Ray
- Drug Screening Assays, Antitumor
- Drugs, Chinese Herbal
(chemistry, isolation & purification, pharmacology)
- Glycosides
- Humans
- Molecular Conformation
- Molecular Structure
- Sesquiterpenes, Eudesmane
(chemistry, isolation & purification, pharmacology)
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