Abstract | BACKGROUND: AIM: To evaluate the effects of metformin on hepatocyte cell death. METHODS: RESULTS:
Metformin dose-dependently reduces GCDCA-induced apoptosis, even when added 2 hours after GCDCA, without increasing necrotic cell death. Metformin does not protect against TNFα/ActD-induced apoptosis. The protective effect of metformin is dependent on an intact PI3-kinase/Akt pathway, but does not require AMPK/mTOR-signaling. Metformin does not inhibit NF-κB activation. CONCLUSION:
|
Authors | Titia E Woudenberg-Vrenken, Laura Conde de la Rosa, Manon Buist-Homan, Klaas Nico Faber, Han Moshage |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 8
Pg. e71773
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23951244
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Bile Acids and Salts
- Hypoglycemic Agents
- NF-kappa B
- Glycochenodeoxycholic Acid
- Metformin
- Proto-Oncogene Proteins c-akt
- TOR Serine-Threonine Kinases
- AMP-Activated Protein Kinases
- Caspase 3
|
Topics |
- AMP-Activated Protein Kinases
(metabolism)
- Animals
- Apoptosis
(drug effects)
- Bile Acids and Salts
(metabolism, pharmacology)
- Caspase 3
(metabolism)
- Cell Membrane
(metabolism)
- Dose-Response Relationship, Drug
- Glycochenodeoxycholic Acid
(metabolism)
- Hepatocytes
(drug effects, metabolism, pathology)
- Hypoglycemic Agents
(pharmacology)
- Male
- Metformin
(pharmacology)
- NF-kappa B
(metabolism)
- Necrosis
(drug therapy)
- Phosphatidylinositol 3-Kinases
(metabolism)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Rats
- Signal Transduction
- TOR Serine-Threonine Kinases
(metabolism)
|