Abstract | INTRODUCTION: METHODS: A retrospective review of all patients who underwent proctocolectomy for familial adenomatous polyposis with construction of an ileal pouch from 1972 to 2007 was performed. Data and status at follow-up were retrieved from the Mayo Clinic Colorectal Surgery Pouch database. RESULTS: One hundred seventeen patients were identified with a median age of 26, 52 were male. Ileal reservoirs included J-pouch (a = 104), Kock pouch (n = 9), S-pouch (n = 3), and W-pouch (n = 1). Median follow-up was 125 months. Polyps were biopsied in 33 patients: non-dysplastic polyps (n = 2), low-grade dysplasia (n = 30), and adenocarcinoma (n = 1). No patients had high-grade dysplasia. Median time to development of dysplasia was 149 months. Adenocarcinoma developed in one patient after 284 months. Risk of dysplasia at 10, 20, and 25 years was 17, 45, and 69%, respectively. CONCLUSION:
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Authors | Sarah Y Boostrom, Kellie L Mathis, Rajesh Pendlimari, Robert R Cima, David W Larson, Eric J Dozois |
Journal | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
(J Gastrointest Surg)
Vol. 17
Issue 10
Pg. 1804-8
(Oct 2013)
ISSN: 1873-4626 [Electronic] United States |
PMID | 23949425
(Publication Type: Journal Article)
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Topics |
- Adenomatous Polyposis Coli
(surgery)
- Adolescent
- Adult
- Child
- Child, Preschool
- Colonic Pouches
(adverse effects)
- Female
- Humans
- Intestinal Neoplasms
(epidemiology, etiology)
- Male
- Middle Aged
- Retrospective Studies
- Risk
- Young Adult
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