Epithelial expression of extracellular matrix metalloproteinase inducer/CD147 and matrix metalloproteinase-2 in neoplasms and precursor lesions derived from cutaneous squamous cells: An immunohistochemical study.

Abstract

Extracellular matrix metalloproteinase inducer (CD147) is a transmembrane glycoprotein involved in the regulation of matrix metalloproteinases (MMPs). The study investigated CD147 and MMP-2 expression in epidermis of cutaneous squamous lesions. CD147 and MMP-2 expressions were evaluated immunohistochemically in 44 specimens: 18 actinic keratoses (AK), 6 squamous cell carcinomas in situ (SCCIS), 13 squamous cell carcinomas (SCC; peritumoral and invasive portions assessed), and 7 normal skins. Patterns of expression were assessed, with MMP-2 in nuclei (MMP-2n) and cytoplasm (MMP-2c) evaluated separately. The expression of each marker was quantified using a calculated immunohistochemical/histologic score (H-score). Correlations were analyzed for the marker H-scores in each study group. Associations between H-scores and histopathologic parameters were also evaluated. CD147 H-score was the highest in SCC (invasive islands), followed by AK, SCCIS, and control specimens, respectively. MMP-2n and MMP-2c H-scores were the highest in AK, followed by SCCIS, SCC, and control specimens, respectively. MMP-2c and MMP-2n H-scores were significantly higher in peritumoral epidermis than in invasive islands of SCC. MMP-2c and CD147 H-scores were positively correlated in the peritumoral SCCs. CD147 H-score was positively correlated with tumor differentiation in SCC. The findings suggest that overexpression of CD147 plays a role in the development of SCC.

• Authors: Sebnem Kupana Ayva, Ayse Anil Karabulut, Ayşe Nur Akatli, Pinar Atasoy, Onder Bozdogan
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 209 Issue 10 Pg. 627-34 (Oct 2013) ISSN: 1618-0631 [Electronic] Germany
• PMID: 23948694 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier GmbH. All rights reserved.

Chemical References

• BSG protein, human
• Biomarkers, Tumor
• Basigin
• Matrix Metalloproteinase 2

Topics

• Adult
• Aged
• Aged, 80 and over
• Basigin (analysis, biosynthesis)
• Biomarkers, Tumor (analysis)
• Carcinoma, Squamous Cell (metabolism)
• Epithelial Cells (metabolism)
• Extracellular Space (enzymology)
• Female
• Humans
• Immunohistochemistry
• Keratosis, Actinic (metabolism)
• Male
• Matrix Metalloproteinase 2 (analysis, biosynthesis)
• Middle Aged
• Precancerous Conditions (metabolism)
• Skin Neoplasms (metabolism)