Abstract | OBJECTIVE: To analyze and compare the demographics, treatment, recurrence, and survival rates in patients with carcinosarcoma of the uterus and ovary. STUDY DESIGN: All patients with uterine and ovarian carcinosarcoma who underwent surgical staging at the 2 participating institutions between 1995 and 2007 were identified. The Kaplan-Meier method was used to generate overall survival (OS) data. Factors predictive of outcome were compared using the Cox proportional hazards model. RESULTS: Analysis of 87 women with uterine carcinosarcoma and 71 with ovarian carcinosarcoma was performed. Of those, 47% of the patients with uterine carcinosarcoma, compared to 14% of the patients with ovarian carcinosarcoma, were diagnosed with localized disease (p < 0.001). Age > 65 years old (p < 0.001), tumor extension (local versus regional versus distant, p < 0.001), and platinum-based chemotherapy (p = 0.05) were all independent predictors of survival. In a multivariate Cox regression model, age > 65 years old (hazard ratio [HR] = 2.5, p < 0.001), tumor extension (locoregional versus distant, HR = 3.9, p = 0.006), and uterine versus ovarian carcinosarcoma (HR = 2.2, p = 0.009) were identified as independent predictors of OS. CONCLUSION:
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Authors | J Alejandro Rauh-Hain, Melina Shoni, John O Schorge, Annekathryn Goodman, Neil S Horowitz, Marcela G del Carmen |
Journal | The Journal of reproductive medicine
(J Reprod Med)
2013 Jul-Aug
Vol. 58
Issue 7-8
Pg. 297-304
ISSN: 0024-7758 [Print] United States |
PMID | 23947079
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Carcinosarcoma
(mortality, pathology, surgery)
- Chemotherapy, Adjuvant
- Disease-Free Survival
- Female
- Humans
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Ovarian Neoplasms
(mortality, pathology, surgery)
- Platinum Compounds
(therapeutic use)
- Prognosis
- Proportional Hazards Models
- Radiotherapy, Adjuvant
- Survival Rate
- Uterine Neoplasms
(mortality, pathology, surgery)
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