Bone dissemination of prostate cancer after holmium laser enucleation of the prostate: a case report and a review of the literature.

Abstract

We report a case of dissemination of prostate cancer after holmium laser enucleation of the prostate in an 80-year-old patient. The patient presented at hospital because of nocturia. Transrectal ultrasound-guided biopsy was carried out because of high serum prostate-specific antigen (3.55 ng/mL), but it showed no malignancies. Benign prostate hyperplasia was diagnosed, and he was started on an α1-blocker. Although the urinary symptom improved with silodosin, acute urinary retention occurred 3 years after therapy began. Holmium laser enucleation of the prostate for relief of bladder outlet obstruction enabled discharge of urine. Pathological examination of the resected tissue found adenocarcinoma with a high Gleason score, 4 + 5. Serum alkaline phosphatase increased rapidly after holmium laser enucleation, and bone scintigraphy confirmed multiple bone metastases. Prostate cancer, T1bN0M1b, was diagnosed.

• Authors: Dai Koguchi, Morihiro Nishi, Takefumi Satoh, Toshiya Shitara, Kazumasa Matsumoto, Tetsuo Fujita, Kazunari Yoshida, Masatsugu Iwamura
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 21 Issue 2 Pg. 215-7 (Feb 2014) ISSN: 1442-2042 [Electronic] Australia
• PMID: 23944756 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © 2013 The Japanese Urological Association.

Topics

• Adenocarcinoma (diagnostic imaging, secondary, surgery)
• Aged, 80 and over
• Bone Neoplasms (diagnostic imaging, secondary)
• Humans
• Laser Therapy (adverse effects)
• Lasers, Solid-State
• Male
• Prostatectomy (adverse effects)
• Prostatic Neoplasms (pathology, surgery)
• Radionuclide Imaging
• Urinary Bladder Neck Obstruction (pathology, surgery)