Intractable epidermolysis bullosa acquisita: efficacy of cyclosporin A.

Abstract

We report the case of a 66-year-old man who presented with a spontaneous blistering involving both skin and mucous membranes, diagnosed as an inflammatory form of epidermolysis bullosa acquisita. During a 5-year course, the condition failed to respond to various therapies. Finally, only ciclosporin, together with a low dose regimen of prednisone, achieved a dramatic improvement with a total clearing within 6 months, persisting 1 1/2 years after discontinuation. Such results prompt us to propose such an association as a primary therapeutic scheme in an otherwise barely tractable disease.

• Authors: C Merle, D Blanc, M Zultak, H van Landuyt, C Drobacheff, R Laurent
• Journal: Dermatologica (Dermatologica) Vol. 181 Issue 1 Pg. 44-7 ( 1990) ISSN: 0011-9075 [Print] Switzerland
• PMID: 2394303 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclosporins
• Prednisone

Topics

• Aged
• Cyclosporins (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Epidermolysis Bullosa (drug therapy, immunology, pathology)
• Humans
• Male
• Microscopy, Electron
• Prednisone (administration & dosage, therapeutic use)
• Skin (ultrastructure)