Abstract | PURPOSE: METHODS: Seventy-two HIV infected patients including 48 HIV/HCV coinfected were enrolled in this study. Insulin resistance was evaluated by Homeostatic Model Assessment (HOMA) indexes. Serum concentrations of IGF-1, adiponectin, chemerin and visfatin were measured by ELISA. RESULTS: Significant correlation between serum IGF-1 level and CD4 lymphocytes count was demonstrated and the lowest values were observed in subjects with CD4<200 cells/μL. Serum concentration of IGF-1 was significantly higher in patients treated with protease inhibitors based regimen compared to non- nucleoside reverse transcriptase inhibitors and healthy subjects. A significant negative correlation between serum concentration of adiponectin and waist-hip ratio as an indicator of central obesity, was found. There were significant positive correlations between serum concentration of chemerin and HOMA1-IR and serum IGF-1 concentration. Serum chemerin was increased in patients with insulin resistance vs. those with preserved insulin sensitivity. CONCLUSIONS:
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Authors | Anna Parfieniuk-Kowerda, Sławomir Lech Czaban, Anna Grzeszczuk, Jerzy Jaroszewicz, Robert Flisiak |
Journal | Cytokine
(Cytokine)
Vol. 64
Issue 1
Pg. 97-102
(Oct 2013)
ISSN: 1096-0023 [Electronic] England |
PMID | 23941777
(Publication Type: Journal Article)
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Copyright | Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Adipokines
- Adiponectin
- Chemokines
- Cytokines
- Intercellular Signaling Peptides and Proteins
- RARRES2 protein, human
- Insulin-Like Growth Factor I
- Nicotinamide Phosphoribosyltransferase
- nicotinamide phosphoribosyltransferase, human
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Topics |
- Adipokines
(blood)
- Adiponectin
(blood)
- Adult
- Aged
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
(metabolism)
- Chemokines
(blood)
- Cytokines
(blood)
- Female
- HIV Infections
(blood, drug therapy, metabolism)
- Hepatitis C
(blood, metabolism)
- Humans
- Insulin Resistance
- Insulin-Like Growth Factor I
(analysis, metabolism)
- Intercellular Signaling Peptides and Proteins
- Male
- Middle Aged
- Nicotinamide Phosphoribosyltransferase
(blood)
- Obesity
(blood)
- Risk Factors
- Waist-Hip Ratio
- Young Adult
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