Detection of obstructive coronary artery disease using regadenoson stress and 82Rb PET/CT myocardial perfusion imaging.

Abstract

UNLABELLED:

Our objective was to study the diagnostic performance of regadenoson (82)Rb myocardial perfusion PET imaging to detect obstructive coronary artery disease (CAD).

METHODS:

We studied 134 patients (mean age, 63 ± 12 y; mean body mass index, 31 ± 9 kg/m(2)) without known CAD (96 with coronary angiography and 38 with low pretest likelihood of CAD). Stress left ventricular ejection fraction (LVEF) minus rest LVEF defined LVEF reserve. The Duke score was used to estimate the anatomic extent of jeopardized myocardium.

RESULTS:

Regadenoson PET had a high sensitivity, 92% (95% confidence interval [CI], 83%-97%), in detecting obstructive CAD, with a normalcy rate of 97% (95% CI, 86%-99%), specificity of 77% (54/70 patients; 95% CI, 66%-86%), and area under the receiver-operator-characteristic curve of 0.847 (95% CI, 0.774-0.903; P < 0.001). Regadenoson PET demonstrated high sensitivity to detect CAD in patients with single-vessel CAD (89%; 95% CI, 70%-98%). The mean LVEF reserve was significantly higher in patients with normal myocardial perfusion imaging results (6.5% ± 5.4%) than in those with mild (4.3 ± 5.1, P = 0.03) and moderate to severe reversible defects (-0.2% ± 8.4%, P = 0.001). Also, mean LVEF reserve was significantly higher in patients with a low likelihood of CAD (7.2% ± 4.5%, P < 0.0001) and mild or moderate jeopardized myocardium than in those with significant jeopardized myocardium (score ≥ 6), -2.8% ± 8.3%.

CONCLUSION:

Regadenoson (82)Rb myocardial perfusion imaging is accurate for the detection of obstructive CAD. LVEF reserve is high in patients without significant ischemia or significant angiographic jeopardized myocardium.

• Authors: Edward Hsiao, Bilal Ali, Ron Blankstein, Hicham Skali, Towhid Ali, John Bruyere Jr, Raymond Y Kwong, Marcelo F Di Carli, Sharmila Dorbala
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 54 Issue 10 Pg. 1748-54 (Oct 2013) ISSN: 1535-5667 [Electronic] United States
• PMID: 23940305 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Purines
• Pyrazoles
• Rubidium Radioisotopes
• Vasodilator Agents
• regadenoson

Topics

• Aged
• Coronary Angiography
• Coronary Artery Disease (diagnostic imaging, physiopathology)
• Humans
• Male
• Middle Aged
• Multimodal Imaging
• Myocardial Perfusion Imaging
• Positron-Emission Tomography
• Purines (pharmacology)
• Pyrazoles (pharmacology)
• Rubidium Radioisotopes
• Stress, Physiological (drug effects)
• Stroke Volume (drug effects)
• Tomography, X-Ray Computed
• Vasodilator Agents (pharmacology)
• Ventricular Dysfunction, Left (diagnostic imaging)