Abstract | BACKGROUND: OBJECTIVE: METHODS: We modified a recently published pharmacokinetic model and ran Monte Carlo simulations accounting for variability in physiologic parameters and their correlations. We evaluated the pharmacokinetic model by comparing simulated plasma PCB-153 levels during pregnancy to serial measurements in 10 pregnant women from another study population. We estimated the association between simulated plasma PCB-153 levels and birth weight using linear regression models. RESULTS: The plasma PCB-153 level profiles generated with the pharmacokinetic model were comparable to measured levels in 10 pregnant women. We estimated a 118-g decrease in birth weight (95% CI: -129, -106 g) for each 1-μg/L increase in simulated cord plasma PCB-153, compared with the 150-g decrease estimated based on the previous meta-analysis. The estimated decrease in birth weight was reduced to -6 g (95% CI: -18, 6 g) when adjusted for simulated gestational weight gain. CONCLUSION: Our findings suggest that associations previously noted between PCB levels and birth weight may be attributable to confounding by maternal weight gain during pregnancy.
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Authors | Marc-André Verner, Robin McDougall, Anders Glynn, Melvin E Andersen, Harvey J Clewell 3rd, Matthew P Longnecker |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 121
Issue 10
Pg. 1219-24
(Oct 2013)
ISSN: 1552-9924 [Electronic] United States |
PMID | 23934733
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Environmental Pollutants
- Polychlorinated Biphenyls
- 2,4,5,2',4',5'-hexachlorobiphenyl
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Topics |
- Birth Weight
(drug effects)
- Computer Simulation
- Environmental Pollutants
(toxicity)
- Female
- Humans
- Infant, Low Birth Weight
- Infant, Newborn
- Male
- Maternal Exposure
- Monte Carlo Method
- Polychlorinated Biphenyls
(blood, toxicity)
- Pregnancy
- Weight Gain
(drug effects)
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