Diverging role for coronin 1 in antiviral CD4+ and CD8+ T cell responses.

Abstract

Coronin 1 is a member of the evolutionary conserved WD repeat protein family and is highly expressed in hematopoietic cells. Coronin 1 is essential for Ca(2+) mobilization upon T cell receptor (TCR) stimulation providing a pro-survival signal for naïve peripheral T cells. Both in mouse and in human, coronin 1 deficiency is associated with severe T cell lymphopenia. In this work, we have analyzed antiviral T cell-mediated immunity in the presence and absence of coronin 1 in vivo after infection with lymphocytic choriomenigitis virus (LCMV) and vesicular stomatitis virus (VSV) in mice. Despite low peripheral T cell numbers we found that LCMV-specific CD8(+) T cell responses were normal in the absence of coronin 1 and kinetics of LCMV-clearance were similar compared to wild type mice. In contrast, CD4(+) T cell responses were profoundly decreased after LCMV- and VSV-infection. We propose that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation.

• Authors: Vincent Sam Yong Tchang, Andrea Mekker, Kerstin Siegmund, Urs Karrer, Jean Pieters
• Journal: Molecular immunology (Mol Immunol) Vol. 56 Issue 4 Pg. 683-92 (Dec 2013) ISSN: 1872-9142 [Electronic] England
• PMID: 23933558 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Microfilament Proteins
• coronin proteins

Topics

• Animals
• CD4-Positive T-Lymphocytes (immunology, metabolism)
• CD8-Positive T-Lymphocytes (immunology, metabolism)
• Flow Cytometry
• Fluorescent Antibody Technique
• Host-Pathogen Interactions (immunology)
• Lymphocyte Activation (genetics, immunology)
• Lymphocytic choriomeningitis virus (immunology, physiology)
• Lymphopenia (genetics, immunology, virology)
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Microfilament Proteins (deficiency, genetics, immunology)
• RNA Virus Infections (genetics, immunology, virology)
• Survival Analysis
• Time Factors
• Vesicular stomatitis Indiana virus (immunology, physiology)