Abstract | BACKGROUND/PURPOSE: METHODS: RESULTS: Histopathological changes in the 5% phenol in almond oil group were significantly different from other groups (p=0.0001). Prominent submucosal fibrosis (grade 3), lymphatic vascular dilation, foreign body reaction, and lipogranuloma were observed in the 5% PAO group (p=0.007). No significant histopathological differences were seen between the 30% saline, 30% dextrose, and 70% ethyl alcohol groups. Significantly increased mucosal fibroblast proliferation (grade 2) was seen in 60% rats of the 30% dextrose group (p=0.026). The cow's milk and ethyl alcohol groups had mucosal erosions and congestion (grade 1) which were significantly different from the control group (p=0.024). No statically significant difference was observed between the 30% saline group and the control group. CONCLUSIONS: In this study we showed that 5% PAO can induce some histopathological changes in the submucosal area that increase the mucosal tightness of the mucosa, which are necessary for the treatment of rectal prolapse.
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Authors | Semire Serin Ezer, Fazilet Kayaselçuk, Pelin Oguzkurt, Abdulkerim Temiz, Emine Ince, Akgun Hicsonmez |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 48
Issue 8
Pg. 1738-43
(Aug 2013)
ISSN: 1531-5037 [Electronic] United States |
PMID | 23932615
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Plant Oils
- Sclerosing Solutions
- Phenol
- Ethanol
- Sodium Chloride
- almond oil
- Glucose
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Topics |
- Animals
- Cattle
- Drug Evaluation, Preclinical
- Ethanol
(administration & dosage, therapeutic use)
- Fibroblasts
(pathology)
- Glucose
(administration & dosage, therapeutic use)
- Intestinal Mucosa
(drug effects, pathology)
- Male
- Milk
- Phenol
(administration & dosage, therapeutic use)
- Plant Oils
(administration & dosage)
- Random Allocation
- Rats
- Rats, Wistar
- Rectal Prolapse
(therapy)
- Rectum
(drug effects, pathology)
- Sclerosing Solutions
(therapeutic use)
- Sclerotherapy
- Sodium Chloride
(administration & dosage, therapeutic use)
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