A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study.

Abstract

OBJECTIVE:

To compare the efficacy of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of the adhesion reformation after hysteroscopic adhesiolysis for Asherman's syndrome.

STUDY DESIGN:

Retrospective cohort study of 107 women with Asherman's syndrome who were treated with hysteroscopic division of intrauterine adhesions. After hysteroscopic adhesiolysis, 20 patients had intrauterine balloon inserted, 28 patients had intrauterine contraceptive device (IUD) fitted, 18 patients had hyaluronic acid gel instilled into the uterine cavity, and 41 control subjects did not have any of the three additional treatment measures. A second-look hysteroscopy was performed in all cases, and the effect of hysteroscopic adhesiolysis was scored by the American Fertility Society classification system.

RESULTS:

Both the intrauterine balloon group and the IUD group achieved significantly (P<0.001) greater reduction in the adhesion score than that of the hyaluronic acid gel group and control group. The efficacy of the balloon was greater than that of the IUD (P<0.001). There was no significant difference in results between the hyaluronic acid gel group and the control groups.

CONCLUSION:

The insertion of an intrauterine balloon or intrauterine device is more effective than the use of hyaluronic acid gel in the prevention of intra-uterine adhesion reformation.

• Authors: Xiaona Lin, Minling Wei, T C Li, Qiongxiao Huang, Dong Huang, Feng Zhou, Songying Zhang
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 170 Issue 2 Pg. 512-6 (Oct 2013) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 23932377 (Publication Type: Comparative Study, Journal Article)
• Copyright: Crown Copyright © 2013. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Gels
• Viscosupplements
• Hyaluronic Acid

Topics

• Adult
• Cohort Studies
• Female
• Gels
• Gynatresia (pathology, prevention & control, surgery)
• Humans
• Hyaluronic Acid (therapeutic use)
• Hysteroscopy
• Intrauterine Devices
• Retrospective Studies
• Secondary Prevention
• Uterus (pathology)
• Viscosupplements (therapeutic use)
• Young Adult