Sympathetic neuropathy and dysphagia following doxycycline sclerotherapy.

Abstract

This case report demonstrates neurologic sequela following treatment with doxycycline sclerotherapy. A six-week-old child presented with respiratory distress from a macrocystic lymphatic malformation, extending from the skull base to the anterior mediastinum. Following doxycycline sclerotherapy, the airway symptoms resolved; however, the child developed silent aspiration and Horner's syndrome. Two months following treatment the patient resumed oral diet and at one year post-intervention there has been no recurrence of symptoms, with only mild ptosis remaining. While neuropathies following doxycycline sclerotherapy have been described, aspiration has never been documented. This case demonstrates a single patient's clinical course and resolution of their neuropathies.

• Authors: Kevin L Wang, Robert H Chun, Joseph E Kerschner, Cecille G Sulman
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 77 Issue 9 Pg. 1613-6 (Sep 2013) ISSN: 1872-8464 [Electronic] Ireland
• PMID: 23931985 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Doxycycline

Topics

• Airway Obstruction (diagnosis, etiology)
• Deglutition Disorders (etiology, physiopathology)
• Doxycycline (adverse effects, therapeutic use)
• Female
• Follow-Up Studies
• Horner Syndrome (etiology, physiopathology)
• Humans
• Infant
• Lymphatic Abnormalities (pathology, therapy)
• Magnetic Resonance Imaging (methods)
• Respiratory Aspiration (etiology, physiopathology)
• Respiratory Distress Syndrome, Newborn (diagnosis, therapy)
• Risk Assessment
• Sclerotherapy (adverse effects, methods)