Abstract | RATIONALE AND OBJECTIVES: MATERIALS AND METHODS: This was a prospective study including 348 patients with hypervascular HCC in 77 hospitals as a postmarketing surveillance to investigate the effects of body weight-tailored dose of CM (300 mgI/mL of iohexol) for hepatic multiphasic contrast-enhanced multidetector-row computed tomography imaging. Informed consent was obtained from all patients who were enrolled. The tumor-to-liver contrast (TLC) of HAP images was assessed qualitatively (QL-TLC) and quantitatively (QT-TLC [HU]; computed tomography [CT] value of tumor-CT value of hepatic parenchyma). Minimal and sufficient QT-TLC were defined as CT values corresponding to the median and 75% of QL-TLC assigned with "good," respectively. The recommended iodine dose was estimated by the relationship between iodine dose (mgI/kg) and QT-TLC. RESULTS: There was a good correlation between QL-TLC and QT-TLC. The recommended iodine dose of CM for HAP imaging was considered to be in the range of 567-647 mgI/kg based on minimal (33.7 HU) and sufficient QT-TLC (40.9 HU). Meanwhile, the recommended dose of CM for HPP imaging was 572 mgI/kg as a dose that gives hepatic enhancement more than 50 HU during HPP imaging. CONCLUSIONS: The recommended iodine dose of CM for HAP and HPP imaging may be different, being 567-647 mgI/kg and 572 mgI/kg, respectively, in assessing hypervascular HCC.
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Authors | Tomoaki Ichikawa, Masahiro Okada, Hiroshi Kondo, Hironobu Sou, Takamichi Murakami, Masayuki Kanematsu, Shushi Yoshikawa, Kazuhito Shiosakai, Akiko Hayakawa, Kazuo Awai, Kengo Yoshimitsu, Yasuyuki Yamashita |
Journal | Academic radiology
(Acad Radiol)
Vol. 20
Issue 9
Pg. 1130-6
(Sep 2013)
ISSN: 1878-4046 [Electronic] United States |
PMID | 23931427
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2013 AUR. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Carcinoma, Hepatocellular
(diagnostic imaging, epidemiology)
- Contrast Media
(administration & dosage)
- Dose-Response Relationship, Drug
- Female
- Hospitals, General
(statistics & numerical data)
- Humans
- Iohexol
(administration & dosage)
- Japan
(epidemiology)
- Liver Neoplasms
(diagnostic imaging, epidemiology)
- Male
- Neovascularization, Pathologic
(diagnostic imaging, epidemiology)
- Prevalence
- Radiographic Image Enhancement
(methods)
- Reproducibility of Results
- Sensitivity and Specificity
- Tomography, X-Ray Computed
(methods, statistics & numerical data)
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