Abstract | BACKGROUND AND PURPOSE: METHODS: In 3440 Framingham Study participants (mean age, 65±11 years; 56% women) who were free of stroke/ transient ischemic attack (TIA), we related baseline BDNF and logVEGF to risk of incident stroke/TIA. In a subsample with brain MRI and with neuropsychological tests available (n=1863 and 2104, respectively; mean age, 61±9 years, 55% women, in each), we related baseline BDNF and logVEGF to log-white matter hyperintensity volume on brain MRI, and to visuospatial memory and executive function tests. RESULTS: During a median follow-up of 10 years, 193 participants experienced incident stroke/TIA. In multivariable analyses adjusted for age, sex, and traditional stroke risk factors, lower BDNF and higher logVEGF levels were associated with an increased risk of incident stroke/TIA (hazard ratio comparing BDNF Q1 versus Q2-Q4, 1.47; 95% confidence interval, 1.09-2.00; P=0.012 and hazard ratio/SD increase in logVEGF, 1.21; 95% confidence interval, 1.04-1.40; P=0.012). Persons with higher BDNF levels had less log-white matter hyperintensity volume (β±SE=-0.05±0.02; P=0.025), and better visual memory (β±SE=0.18±0.07; P=0.005). CONCLUSIONS: Lower serum BDNF and higher VEGF concentrations were associated with increased risk of incident stroke/TIA. Higher levels of BDNF were also associated with less white matter hyperintensity and better visual memory. Our findings suggest that circulating BDNF and VEGF levels modify risk of clinical and subclinical vascular brain injury.
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Authors | Aleksandra Pikula, Alexa S Beiser, Tai C Chen, Sarah R Preis, Demetrios Vorgias, Charles DeCarli, Rhoda Au, Margaret Kelly-Hayes, Carlos S Kase, Philip A Wolf, Ramachandran S Vasan, Sudha Seshadri |
Journal | Stroke
(Stroke)
Vol. 44
Issue 10
Pg. 2768-75
(Oct 2013)
ISSN: 1524-4628 [Electronic] United States |
PMID | 23929745
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Brain-Derived Neurotrophic Factor
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- BDNF protein, human
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Topics |
- Age Factors
- Aged
- Brain Ischemia
(blood, diagnostic imaging, epidemiology)
- Brain-Derived Neurotrophic Factor
(blood)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Radiography
- Risk Factors
- Sex Factors
- Stroke
(blood, diagnostic imaging, epidemiology)
- Vascular Endothelial Growth Factor A
(blood)
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