[Blood and urine determinations of tissue polypeptide antigen in patients with bladder carcinoma].

Abstract

The Tissue Polypeptide Antigen (TPA) is an oncofetal antigen widely used in the diagnosis and follow-up of several urothelial cancers. Its urinary and serum detection is performed by means of RIA technique. We determined urinary and serum TPA in 30 patients with bladder cancer who underwent a transurethral resection. Ten out of 30 patients were correctly diagnosed by serum TPA, 22 by urinary TPA. The ANOVA test showed a statistically significant correlation between grade and urinary TPA between stage and serum TPA. Urinary TPA showed a good sensibility in low grade and moreover in Ta stage carcinoma. Serum TPA increased its performance with higher grade carcinoma and in presence of a muscle infiltration, but it never reached a sufficient sensibility to be considered a bladder cancer marker. In conclusion the simultaneous determination of urinary and serum TPA does not give more information than the urinary determination alone.

• Authors: A Tizzani, G Casetta, A Cavallini, P Piana, P Piantino
• Journal: Minerva urologica e nefrologica = The Italian journal of urology and nephrology (Minerva Urol Nefrol) 1990 Apr-Jun Vol. 42 Issue 2 Pg. 69-71 ISSN: 0393-2249 [Print] Italy
• Vernacular Title: Determinazione sierica ed urinaria del Tissue Polypeptide Antigen (TPA) nei pazienti affetti da carcinoma vescicale.
• PMID: 2392743 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Peptides
• Tissue Polypeptide Antigen

Topics

• Antigens, Neoplasm (analysis)
• Biomarkers, Tumor (analysis)
• Carcinoma, Transitional Cell (analysis, pathology)
• Female
• Humans
• Male
• Peptides (analysis)
• Predictive Value of Tests
• Radioimmunoassay
• Tissue Polypeptide Antigen
• Urinary Bladder Neoplasms (analysis, pathology)