Carotid intima-media thickness in children with Kawasaki disease.

Kawasaki disease (KD) is an acute medium vessel vasculitis seen in children. The most significant long-term complication is related to coronary artery abnormalities. Use of intravenous immunoglobulins, however, has led to significant reduction in incidence of coronary aneurysms. What is more alarming is the fact that higher risk of cardiovascular disease is seen in even those children who do not have coronary artery aneurysms during subacute phase. Various factors like abnormal lipid profiles, abnormal vessel wall reactivity and endothelial dysfunction have been implicated for this. Carotid intima-media thickness (cIMT) has been used as a surrogate marker for atherosclerosis. This study was planned to evaluate cIMT in children with KD. Twenty-seven children with diagnosis of KD at least 1 year prior to enrolment were evaluated for cIMT at enrolment and then after 3 months. Fasting lipid profile was done for all patients. Mean cIMT was significantly higher in children with KD compared to controls. In lipid profiles, undesirable HDL-C and triglyceride levels were seen in 2 and 3 children, respectively. Undesirable and borderline LDL-C levels were seen in 1 and 2 patients, respectively. Undesirable and borderline total cholesterol levels were seen in 1 and 3 patients, respectively. Higher cIMTs were seen in our cohort of KD patients. Proatherogenic abnormalities in lipid profile were seen in a few patients. Both abnormalities may predict a higher risk of atherosclerosis in future. The results of this study need to be replicated on a larger study sample and over longer follow-up periods.
AuthorsRaghvendra Singh Meena, Manojkumar Rohit, Anju Gupta, Surjit Singh
JournalRheumatology international (Rheumatol Int) Vol. 34 Issue 8 Pg. 1117-21 (Aug 2014) ISSN: 1437-160X [Electronic] Germany
PMID23925993 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Age Factors
  • Biomarkers (blood)
  • Carotid Arteries (ultrasonography)
  • Carotid Artery Diseases (blood, ultrasonography)
  • Carotid Intima-Media Thickness
  • Case-Control Studies
  • Child
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Female
  • Humans
  • Male
  • Mucocutaneous Lymph Node Syndrome (blood, ultrasonography)
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Time Factors

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