Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis.

Abstract

OBJECTIVE:

To analyze the prevalence of myositis-specific and myositis-associated autoantibodies and their clinical correlations in a large series of patients with dermatomyositis/polymyositis.

METHOD:

This cross-sectional study enrolled 127 dermatomyositis cases and 95 polymyositis cases. The disease-related autoantibody profiles were determined using a commercially available blood testing kit.

RESULTS:

The prevalence of myositis-specific autoantibodies in all 222 patients was 34.4%, whereas myositis-associated autoantibodies were found in 41.4% of the patients. The most frequently found autoantibody was anti-Ro-52 (36.9%), followed by anti-Jo-1 (18.9%), anti-Mi-2 (8.1%), anti-Ku (4.1%), anti-SRP (3.2%), anti-PL-7 (3.2%), anti-PL-12 (2.7%), anti-PM/Scl75 (2.7%), and anti-PM/Scl100 (2.7%). The distributions of these autoantibodies were comparable between polymyositis and dermatomyositis, except for a higher prevalence of anti-Jo-1 in polymyositis. Anti-Mi-2 was more prevalent in dermatomyositis. Notably, in the multivariate analysis, anti-Mi-2 and anti-Ro-52 were associated with photosensitivity and pulmonary disorders, respectively, in dermatomyositis. Anti-Jo-1 was significantly correlated with pulmonary disorders in polymyositis. Moreover, anti-Ro-52 was associated with anti-Jo-1 in both diseases. No significant correlation was observed between the remaining autoantibodies and the clinical and/or laboratory findings.

CONCLUSIONS:

Our data are consistent with those from other published studies involving other populations, although certain findings warrant consideration. Anti-Ro-52 and anti-Jo-1 were strongly associated with one another. Anti-Ro-52 was correlated with pulmonary disorders in dermatomyositis, whereas anti-Jo-1 was correlated with pulmonary alterations in polymyositis.

• Authors: Marcela Gran Pina Cruellas, Vilma dos Santos Trindade Viana, Maurício Levy-Neto, Fernando Henrique Carlos de Souza, Samuel Katsuyuki Shinjo
• Journal: Clinics (Sao Paulo, Brazil) (Clinics (Sao Paulo)) Vol. 68 Issue 7 Pg. 909-14 (Jul 2013) ISSN: 1980-5322 [Electronic] United States
• PMID: 23917652 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Mi-2 antibodies
• Ribonucleoproteins
• SS-A antigen

Topics

• Adult
• Age of Onset
• Autoantibodies (blood)
• Cross-Sectional Studies
• Dermatomyositis (blood, immunology)
• Female
• Humans
• Logistic Models
• Lung Diseases (blood, immunology)
• Male
• Middle Aged
• Muscle Strength
• Myositis (blood, immunology)
• Ribonucleoproteins (blood)
• Statistics, Nonparametric
• Time Factors