Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: CV outcomes were not associated with ER niacin in any baseline lipoprotein tertile. In a subset of patients in both the highest triglyceride (≥ 198 mg/dl) and lowest HDL-C (<33 mg/dl) tertiles, ER niacin showed a trend toward benefit (hazard ratio: 0.74, p = 0.073). In-trial LDL-C levels, non-HDL-C levels, and the total cholesterol/HDL-C ratio were positively associated with CV events in the control group, but these relationships were absent in the ER niacin group. CONCLUSIONS: Baseline lipoprotein tertiles did not predict differential benefit or harm with ER niacin added to LDL-C-lowering therapy, but a small dyslipidemic subgroup may benefit. ER niacin attenuated expected relationships of lipoprotein risk factors with CV events, raising the possibility that nonlipoprotein actions of niacin could affect risk. ( Niacin Plus Statin to Prevent Vascular Events [AIM-HIGH]; NCT00120289).
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Authors | John R Guyton, April E Slee, Todd Anderson, Jerome L Fleg, Ronald B Goldberg, Moti L Kashyap, Santica M Marcovina, Stephen D Nash, Kevin D O'Brien, William S Weintraub, Ping Xu, Xue-Qiao Zhao, William E Boden |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 62
Issue 17
Pg. 1580-4
(Oct 22 2013)
ISSN: 1558-3597 [Electronic] United States |
PMID | 23916935
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anticholesteremic Agents
- Biomarkers
- Cholesterol, HDL
- Lipoproteins
- Triglycerides
- Niacin
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Topics |
- Aged
- Anticholesteremic Agents
(administration & dosage)
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, drug therapy, epidemiology)
- Cholesterol, HDL
(blood)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Global Health
- Humans
- Lipoproteins
(blood)
- Male
- Metabolic Syndrome
(blood, drug therapy, epidemiology)
- Middle Aged
- Niacin
(administration & dosage)
- Prospective Studies
- Treatment Outcome
- Triglycerides
(blood)
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