A randomized trial comparing thulium laser resection to standard transurethral resection of the prostate for symptomatic benign prostatic hyperplasia: four-year follow-up results.

Abstract

OBJECTIVE:

To report the results of a randomized prospective trial with a 4-year follow-up, comparing the thulium laser resection of the prostate-tangerine technique (TmLRP-TT) with transurethral resection of prostate (TURP) for treatment of symptomatic benign prostatic hyperplasia (BPH).

METHODS:

BPH patients (96) were randomized for surgical treatment with TmLRP-TT (47) or TURP (49). All patients were assessed pre-operatively and followed at 12, 24, 36, and 48 months post-operatively. Several parameters related to BPH were collected at each follow-up, including International Prostate Symptom Score (IPSS), quality of life (QoL), maximum urinary flow rates (Qmax), and post-void residual volume (PVR). All late complications were also recorded.

RESULTS:

Dramatic improvement in micturition parameters was observed after TmLRP-TT compared with pre-operative values. Median IPSS decreased 75.6 % in the subsequent 12 months and 61.2 % in 48 months, while median QoL decreased by 80.4 and 59.1 %, respectively. Compared with baseline, numerical values of Qmax increased 1.07-fold and those of PVR decreased 73.1 % in the fourth year. Moreover, all micturition parameters in the TmLRP-TT group were similar to those of TURP patients at every annual assessment. Some late complications after the operations were also observed: one patient suffered from urethral strictures and one from bladder-neck contractures after TmLRP-TT. Re-operation rates were equal in the two groups.

CONCLUSIONS:

Micturition remained stable after TmLRP-TT during the 4-year follow-up. Outcomes compared favourably with TURP, with lower peri-operative morbidity and equally low occurrence of late adverse effects. Thus, TmLRP-TT can be an available option for BPH patients, especially older, high-risk patients.

• Authors: Di Cui, Feng Sun, Jian Zhuo, Xiaowen Sun, Bangmin Han, Fujun Zhao, Yifeng Jing, Jun Lu, Shujie Xia
• Journal: World journal of urology (World J Urol) Vol. 32 Issue 3 Pg. 683-9 (Jun 2014) ISSN: 1433-8726 [Electronic] Germany
• PMID: 23913094 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Topics

• Aged
• Aged, 80 and over
• Follow-Up Studies
• Humans
• Laser Therapy (methods)
• Lasers, Solid-State (therapeutic use)
• Male
• Middle Aged
• Prospective Studies
• Prostatic Hyperplasia (diagnosis, surgery)
• Time Factors
• Transurethral Resection of Prostate (methods)
• Treatment Outcome