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Ureaplasma urealyticum and Ureaplasma parvum in women of reproductive age.

AbstractOBJECTIVES:
To determine the incidence of Ureaplasma urealyticum and Ureaplasma parvum (UP) in symptomatic and asymptomatic women of reproductive age and to estimate antibiotic susceptibility of ureaplasma isolates.
MATERIALS AND METHODS:
This study included 424 ureaplasma positive women of 1,370 tested women who visited gynecological practices during 2010. Cervicovaginal or urethral swab specimens from each patient were obtained for cultivation and molecular typing by RT-PCR.
RESULTS:
Ureaplasma spp. was identified by cultivation in 424 (34.4 %) cases, of which 79.0 % were from women with symptoms and 21.0 % from women without symptoms. Among ureaplasma positive women, 121 (28.5 %) were pregnant. Genotyping was successful in 244 strains, and the majority of samples were identified as UP (92.6 %). Among genotyped isolates, there were 79.5 % from symptomatic and 20.5 % from asymptomatic women; 29.9 % from pregnant and 70.1 % from non-pregnant women. There was no difference in the incidence of ureaplasma type regarding symptoms. Antibiotic susceptibility of 424 ureaplasma isolates identified by cultivation showed that all strains were susceptible to doxycycline, josamycin, erythromycin, tetracycline, clarithromycin and pristinamycin, but there was lower susceptibility to quinolone antibiotics, i.e., 42.9 and 24.5 % isolates were susceptible to ofloxacin and ciprofloxacin, respectively.
CONCLUSION:
This study shows that UP was the most frequent isolated ureaplasma species (92.6 %). Regarding antibiotic susceptibility, quinolones are not the best choice for the treatment of ureaplasma infections, while macrolides and tetracyclines are still effective.
AuthorsBlaženka Hunjak, Ivan Sabol, Gordana Vojnović, Ivan Fistonić, Andrea Babić Erceg, Zdenka Peršić, Magdalena Grce
JournalArchives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 289 Issue 2 Pg. 407-12 (Feb 2014) ISSN: 1432-0711 [Electronic] Germany
PMID23912532 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Croatia (epidemiology)
  • Female
  • Genotype
  • Humans
  • Incidence
  • Microbial Sensitivity Tests
  • Middle Aged
  • Pregnancy
  • Pregnancy Complications, Infectious (drug therapy, epidemiology)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ureaplasma (drug effects, isolation & purification)
  • Ureaplasma Infections (drug therapy, epidemiology)
  • Ureaplasma urealyticum (drug effects, isolation & purification)

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