Percutaneous valved stent implantation in the ascending aorta for the treatment of very high-risk aortic regurgitation: an animal study.

Abstract

PURPOSE:

We investigated the effects of percutaneous valved stent implantation in the ascending aorta as an alternative treatment for aortic regurgitation in a canine model.

MATERIALS AND METHODS:

A total of 16 healthy dogs weighing an average of 18.3 ± 2.1 kg were used for the establishment of animal models of chronic aortic regurgitation by percutaneous aortic valve perforation and balloon dilation. At 2 mo after successful model establishment, all experimental animals underwent valved stent implantation in the ascending aorta and then were followed up for 3 mo.

RESULTS:

Experimental models of chronic aortic regurgitation were successfully established in 10 dogs. Surviving dogs underwent successful valved stent implantation in the ascending aorta and were subsequently followed up for 3 mo. The level of instantaneous aortic regurgitation at 3-mo follow-up was significantly reduced compared with that before valved stent implantation (2.4 ± 0.9 versus 10.6 ± 2.1 mL/s, P < 0.05). The left ventricular ejection fraction was significantly increased (53.8 ± 4.2% versus 37.8 ± 3.7%, P < 0.05), and the left ventricular end-diastolic volume was also significantly reduced (30.3 ± 2.2 versus 40.1 ± 3.6 mL, P < 0.05). No paravalvular leak, stroke, atrioventricular block, or other complications occurred in dogs undergoing valved stent implantation.

CONCLUSIONS:

Percutaneous valved stent implantation in the ascending aorta is feasible, effective, and safe as an alternative treatment for very high-risk aortic regurgitation in a canine model.

• Authors: Gang-Jun Zong, Hai-Bin Jiang, Yuan Bai, Gang-Yong Wu, Guang-Ming Ye, Jing-Kai Chen, Yong-Wen Qin, Xian-xian Zhao
• Journal: The Journal of surgical research (J Surg Res) Vol. 185 Issue 2 Pg. 940-4 (Dec 2013) ISSN: 1095-8673 [Electronic] United States
• PMID: 23910885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Topics

• Animals
• Aorta (physiopathology)
• Aortic Valve (physiopathology, surgery)
• Aortic Valve Insufficiency (epidemiology, physiopathology, surgery)
• Bicuspid Aortic Valve Disease
• Chronic Disease
• Disease Models, Animal
• Dogs
• Feasibility Studies
• Female
• Heart Defects, Congenital (epidemiology, physiopathology, surgery)
• Heart Valve Diseases (epidemiology, physiopathology, surgery)
• Heart Valve Prosthesis Implantation (methods)
• Male
• Postoperative Complications (prevention & control)
• Prosthesis Design
• Risk Factors
• Stents