The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans.

Abstract

OBJECTIVE:

To evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings.

MATERIAL AND METHODS:

Commercially pure (cp) titanium mini-implants (n = 13) or nano-hydroxyapatite-coated ones (n = 12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1 week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8 weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically.

RESULTS:

No statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p = .438), TGF-β2 (p = .467), MMP-8 (p = .758), CCL-3 (p = .758), IL-8 (p = .771), and IL-1β (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p = .669).

CONCLUSION:

Nano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.

• Authors: Elisabeth A W J De Wilde, Ryo Jimbo, Ann Wennerberg, Yoshihito Naito, Paul Coucke, Matthew S Bryington, Stefan Vandeweghe, Hugo De Bruyn
• Journal: Clinical implant dentistry and related research (Clin Implant Dent Relat Res) Vol. 17 Suppl 1 Pg. e65-74 (Jan 2015) ISSN: 1708-8208 [Electronic] United States
• PMID: 23910386 (Publication Type: Journal Article)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Biocompatible Materials
• Coated Materials, Biocompatible
• Dental Implants
• Durapatite
• Titanium

Topics

• Aged
• Biocompatible Materials
• Biopsy
• Coated Materials, Biocompatible
• Dental Implantation, Endosseous (methods)
• Dental Implants
• Durapatite (immunology)
• Female
• Gene Expression
• Gingival Crevicular Fluid (immunology)
• Humans
• Jaw, Edentulous, Partially (rehabilitation)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Surface Properties
• Titanium (immunology)
• Treatment Outcome