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Efficacy of topiramate as add-on therapy in two different types of progressive myoclonic epilepsy.

Abstract
The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora's disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy.
AuthorsCaner Feyzi Demir, Hasan Hüseyin Ozdemir, Bülent Müngen
JournalActa medica (Hradec Kralove) (Acta Medica (Hradec Kralove)) Vol. 56 Issue 1 Pg. 36-8 ( 2013) ISSN: 1211-4286 [Print] Czech Republic
PMID23909054 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticonvulsants
  • Topiramate
  • Fructose
Topics
  • Anticonvulsants (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Fructose (analogs & derivatives, therapeutic use)
  • Humans
  • Myoclonic Epilepsies, Progressive (drug therapy)
  • Topiramate
  • Young Adult

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