[Family diabetes and its consequences in cancer patients].

Abstract

Preliminary data are confirmed on the more rare prevalence of family history of diabetes mellitus (DM) in cancer patients, mainly females, with diabetes in comparison with diabetics without cancer pathology. Familial diabetes does not worsen additionally tumor characteristics against the same in patients with non-familial diabetes. More than that, familial diabetes in diabetics with breast cancer goes together with lesser size of tumor and demonstrates an inclination to the rarer distant metastases in breast and endometrial cancer patients. The signs of systemic DNA damage (evaluated, in particular, on the basis of 8-OH-dG serum levels) are pronounced in postmenopausal diabetic cancer patients with familial diabetes in lesser degree than in non-familial variant of DM. In toto, this allows to consider family history of DM in patients with type-2 diabetes as a particular factor of tumor growth containment, which mechanisms and causes, warrant further studies.

• Authors: L M Bershteĭn, D A Vasil'ev, M P Boiarkina, E A Turkevich, G A Dashian, T E Poroshina, E V Tsyrlina, I M Kovalenko, O G Kriukova
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 59 Issue 3 Pg. 352-7 ( 2013) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 23909037 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• 8-Hydroxy-2'-Deoxyguanosine
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Aged
• Biomarkers, Tumor (blood)
• Breast Neoplasms (blood, epidemiology, genetics, pathology)
• DNA Damage
• Deoxyguanosine (analogs & derivatives, blood)
• Diabetes Mellitus, Type 2 (genetics)
• Endometrial Neoplasms (blood, epidemiology, genetics, pathology)
• Female
• Humans
• Incidence
• Male
• Middle Aged
• Postmenopause