The anabolic effect of teriparatide is undermined by low levels of high-density lipoprotein cholesterol.

Abstract

Intermittent parathyroid hormone (PTH) administration has a potent ability to increase bone mass, regardless of underlying conditions or species. A recent study using LDLR(-/-) mice showed that the anabolic effect of PTH was blunted by hyperlipidemia, whereas PTH anabolism was rescued by enhancement of high-density lipoprotein cholesterol (HDL-C) function. We conducted a retrospective longitudinal study to determine whether lipid profiles also affect the anabolic effect of intermittent PTH treatment in humans. Fifty-two patients (8 males and 44 females, ages 38-85 years) with severe osteoporosis who had been treated with teriparatide (TPTD, recombinant human PTH(1-34) for 12 months were studied at Severance Hospital, Yonsei University. C-telopeptide (CTX) and osteocalcin (OCN) were measured at 0, 3, and 12 months; and total cholesterol, triglycerides, and HDL-C were measured at baseline. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at 0 and 12 months. Lumbar spine BMD increased significantly after 12 months of treatment with TPTD (10.0 ± 9.3%, p < 0.001). Initial 3-month changes in CTX and OCN levels revealed positive correlations with the increase in lumbar BMD (r = 0.546, p = 0.001 and r = 0.500, p = 0.006, respectively). Moreover, percentage change in lumbar BMD at 12 months showed a negative correlation with baseline total cholesterol (r = -0.438, p = 0.009) and a positive correlation with HDL-C (r = 0.498, p = 0.016). A smaller 3-month increase in OCN and a lower HDL-C level at baseline were associated with a smaller lumbar BMD increase after TPTD treatment, even after adjustment for age, sex, and other confounding factors (β = 0.462, p = 0.031 for ΔOCN and β = 0.670, p = 0.004 for HDL-C). Plasma levels of lipids, especially HDL-C, seem to be associated with the extent of osteoanabolic effects of TPTD in humans.

• Authors: Yun Kyung Jeon, Kyoung Min Kim, Kwang Joon Kim, In Joo Kim, Sung-Kil Lim, Yumie Rhee
• Journal: Calcified tissue international (Calcif Tissue Int) Vol. 94 Issue 2 Pg. 159-68 (Feb 2014) ISSN: 1432-0827 [Electronic] United States
• PMID: 23907724 (Publication Type: Journal Article)

Chemical References

• Anabolic Agents
• Bone Density Conservation Agents
• Cholesterol, HDL
• Teriparatide

Topics

• Adult
• Aged
• Aged, 80 and over
• Anabolic Agents (pharmacology, therapeutic use)
• Bone Density (drug effects)
• Bone Density Conservation Agents (pharmacology, therapeutic use)
• Cholesterol, HDL (blood)
• Female
• Humans
• Longitudinal Studies
• Male
• Middle Aged
• Osteoporosis (blood, drug therapy)
• Retrospective Studies
• Teriparatide (pharmacology, therapeutic use)
• Treatment Outcome