Abstract | STUDY OBJECTIVES: DESIGN: Randomized controlled trial. SETTING: Sleep center. PATIENTS: INTERVENTIONS: NPPV or servoventilation. MEASUREMENTS AND RESULTS: Patients were randomized to NPPV or servo-ventilation. Full polysomnography (PSG) was performed after 6 weeks. On CPAP prior to randomization, patients in the NPPV and servoventilator arm had comparable apnea-hypopnea indices (AHI, 28.6 ± 6.5 versus 27.7 ± 9.7 events/h (mean ± standard deviation [SD])), apnea indices (AI,19 ± 5.6 versus 21.1 ± 8.6 events/h), central apnea indices (CAI, 16.7 ± 5.4 versus 18.2 ± 7.1 events/h), oxygen desaturation indices (ODI,17.5 ± 13.1 versus 24.3 ± 11.9 events/h). During initial titration NPPV and servoventilation significantly improved the AHI (9.1 ± 4.3 versus 9 ± 6.4 events/h), AI (2 ± 3.1 versus 3.5 ± 4.5 events/h) CAI (2 ± 3.1 versus 2.5 ± 3.9 events/h) and ODI (10.1 ± 4.5 versus 8.9 ± 8.4 events/h) when compared to CPAP treatment (all P < 0.05). After 6 weeks we observed the following differences: AHI (16.5 ± 8 versus 7.4 ± 4.2 events/h, P = 0.027), AI (10.4 ± 5.9 versus 1.7 ± 1.9 events/h, P = 0.001), CAI (10.2 ± 5.1 versus 1.5 ± 1.7 events/h, P < 0.0001)) and ODI (21.1 ± 9.2 versus 4.8 ± 3.4 events/h, P < 0.0001) for NPPV and servoventilation, respectively. Other sleep parameters were unaffected by any form of treatment. CONCLUSIONS: After 6 weeks, servoventilation treated respiratory events more effectively than NPPV in patients with complex sleep apnea syndrome.
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Authors | Dominic Dellweg, Jens Kerl, Ekkehard Hoehn, Markus Wenzel, Dieter Koehler |
Journal | Sleep
(Sleep)
Vol. 36
Issue 8
Pg. 1163-71
(Aug 01 2013)
ISSN: 1550-9109 [Electronic] United States |
PMID | 23904676
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Topics |
- Continuous Positive Airway Pressure
(adverse effects)
- Female
- Humans
- Male
- Middle Aged
- Polysomnography
- Positive-Pressure Respiration
(methods)
- Sleep Apnea, Central
(etiology, physiopathology, therapy)
- Sleep Apnea, Obstructive
(physiopathology, therapy)
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