Treatment of type II endoleak using Onyx with long-term imaging follow-up.

The purpose of our study is to report our experience with the use of an ethylene vinyl alcohol copolymer (Onyx) in an off-label fashion for the treatment of type II endoleak after endovascular repair of the thoracic (TEVAR) and abdominal (EVAR) aorta.
A retrospective review of patients with type I and/or II endoleak treated with Onyx was performed. Data regarding the technical, clinical, and imaging outcomes were collected. Technical success was defined as decreased or eliminated endoleak on the first imaging follow-up. Clinical success was defined as unchanged or decreased aneurysm sac size on subsequent follow-up.
Eighteen patients (15 male, 3 female) with a mean age of 79 years (range 69-92) met inclusion criteria (16 abdominal aortic aneurysm, 2 thoracic aortic aneurysm). Sixteen patients had type II endoleak, and 2 had complex type II endoleak with a type I component. The interval between endograft placement and treatment was a mean of 30 months. Direct sac treatment approach was used in 13 patients; transarterial approach was used in 3 patients. Seven patients required the use of coils, N-butyl cyanoacrylate glue, or Amplatzer vascular plugs. The average volume of Onyx used per treatment was 5.6 mL (range 2.5-13). Duration of imaging follow-up was 0.75-72.5 months (mean 32.8). Sixteen of 18 (88.9 %) patients had initial technical and clinical success. Two of 18 patients (11.1 %) were initial technical failures, and 1 remained a failure despite a second treatment and attempted surgical ligation. Eight of 18 (44.4 %) of patients eventually required a second intervention, 5 (27.8 %) of them due to delayed clinical failure. Complications included 1 psoas hematoma, 1 transient L2 nerve paresis, and 1 intraperitoneal Onyx leak; all of these were without clinical sequelae.
Onyx with or without coil/glue/Amplatzer plug embolization is safe and useful in the treatment of type II endoleak after TEVAR and EVAR. However, long-term clinical and imaging follow-up is needed for early detection and management of recurrence of the primary endoleak or the development of new, secondary endoleaks or enlargement of the aneurysm sac.
AuthorsMinhaj S Khaja, Auh Whan Park, Warren Swee, Avery J Evans, J Fritz Angle, Ulku C Turba, Saher S Sabri, Alan H Matsumoto
JournalCardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 37 Issue 3 Pg. 613-22 (Jun 2014) ISSN: 1432-086X [Electronic] United States
PMID23903786 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cyanoacrylates
  • Onyx copolymer
  • Polyvinyls
  • Dimethyl Sulfoxide
  • Aged
  • Aged, 80 and over
  • Aortic Aneurysm, Abdominal (surgery)
  • Aortic Aneurysm, Thoracic (surgery)
  • Cyanoacrylates (therapeutic use)
  • Dimethyl Sulfoxide (therapeutic use)
  • Embolization, Therapeutic (methods)
  • Endoleak (therapy)
  • Endovascular Procedures
  • Female
  • Humans
  • Ligation
  • Male
  • Off-Label Use
  • Polyvinyls (therapeutic use)
  • Retreatment
  • Retrospective Studies
  • Septal Occluder Device
  • Treatment Outcome

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