Abstract |
A 67-year-old Japanese man with recurrent nephrotic syndrome and impaired kidney function had a sporadic, elderly-onset case of glomerulopathy with fibronectin deposits. The daily urinary protein, serum albumin, blood urea nitrogen, and creatinine levels were 3.6 g/day, 2.7 g/dL, 19.5 mg/dL, and 1.70 mg/dL, respectively. Kidney biopsy samples were evaluated using electron microscopy and demonstrated membranoproliferative glomerulonephritis-like lesions with massive subendothelial depositions and no fibrillary structures. Immunofluorescent studies showed 1+ staining for IgA, C1q, and fibrinogen. Anti- fibronectin immunostaining demonstrated that the subendothelial deposits were positive for fibronectin. The administration of prednisolone and mizoribine improved the nephrotic syndrome.
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Authors | Masabumi Yoshino, Naoto Miura, Takahiro Ohnishi, Keisuke Suzuki, Wataru Kitagawa, Kazuhiro Nishikawa, Hirokazu Imai |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 52
Issue 15
Pg. 1715-20
( 2013)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 23903505
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Fibronectins
- Immunoglobulin A
- Ribonucleosides
- mizoribine
- Complement C1q
- Fibrinogen
- Prednisolone
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Topics |
- Age of Onset
- Aged
- Complement C1q
(metabolism)
- Fibrinogen
(metabolism)
- Fibronectins
(metabolism)
- Glomerulonephritis, Membranoproliferative
(drug therapy, metabolism, pathology)
- Humans
- Immunoglobulin A
(metabolism)
- Kidney
(metabolism, pathology)
- Male
- Prednisolone
(therapeutic use)
- Ribonucleosides
(therapeutic use)
- Treatment Outcome
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