Clinicopathological analysis of glomerulopathy with fibronectin deposits (GFND): a case of sporadic, elderly-onset GFND with codeposition of IgA, C1q, and fibrinogen.

Abstract

A 67-year-old Japanese man with recurrent nephrotic syndrome and impaired kidney function had a sporadic, elderly-onset case of glomerulopathy with fibronectin deposits. The daily urinary protein, serum albumin, blood urea nitrogen, and creatinine levels were 3.6 g/day, 2.7 g/dL, 19.5 mg/dL, and 1.70 mg/dL, respectively. Kidney biopsy samples were evaluated using electron microscopy and demonstrated membranoproliferative glomerulonephritis-like lesions with massive subendothelial depositions and no fibrillary structures. Immunofluorescent studies showed 1+ staining for IgA, C1q, and fibrinogen. Anti-fibronectin immunostaining demonstrated that the subendothelial deposits were positive for fibronectin. The administration of prednisolone and mizoribine improved the nephrotic syndrome.

• Authors: Masabumi Yoshino, Naoto Miura, Takahiro Ohnishi, Keisuke Suzuki, Wataru Kitagawa, Kazuhiro Nishikawa, Hirokazu Imai
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 52 Issue 15 Pg. 1715-20 ( 2013) ISSN: 1349-7235 [Electronic] Japan
• PMID: 23903505 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Fibronectins
• Immunoglobulin A
• Ribonucleosides
• mizoribine
• Complement C1q
• Fibrinogen
• Prednisolone

Topics

• Age of Onset
• Aged
• Complement C1q (metabolism)
• Fibrinogen (metabolism)
• Fibronectins (metabolism)
• Glomerulonephritis, Membranoproliferative (drug therapy, metabolism, pathology)
• Humans
• Immunoglobulin A (metabolism)
• Kidney (metabolism, pathology)
• Male
• Prednisolone (therapeutic use)
• Ribonucleosides (therapeutic use)
• Treatment Outcome