Proteomic approaches and identification of novel therapeutic targets for alcoholism.

Abstract

Recent studies have shown that gene regulation is far more complex than previously believed and does not completely explain changes at the protein level. Therefore, the direct study of the proteome, considerably different in both complexity and dynamicity to the genome/transcriptome, has provided unique insights to an increasing number of researchers. During the past decade, extraordinary advances in proteomic techniques have changed the way we can analyze the composition, regulation, and function of protein complexes and pathways underlying altered neurobiological conditions. When combined with complementary approaches, these advances provide the contextual information for decoding large data sets into meaningful biologically adaptive processes. Neuroproteomics offers potential breakthroughs in the field of alcohol research by leading to a deeper understanding of how alcohol globally affects protein structure, function, interactions, and networks. The wealth of information gained from these advances can help pinpoint relevant biomarkers for early diagnosis and improved prognosis of alcoholism and identify future pharmacological targets for the treatment of this addiction.

• Authors: Giorgio Gorini, R Adron Harris, R Dayne Mayfield
• Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology) Vol. 39 Issue 1 Pg. 104-30 (Jan 2014) ISSN: 1740-634X [Electronic] England
• PMID: 23900301 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Biomarkers
• Ion Channels

Topics

• Alcoholism (drug therapy, metabolism)
• Animals
• Biomarkers (metabolism)
• Brain (metabolism)
• Drug Discovery (methods)
• Gene Expression Regulation
• Humans
• Ion Channels (metabolism)
• Molecular Targeted Therapy (methods)
• Proteomics (methods)
• Systems Biology (methods)