Abstract | BACKGROUND: METHODS: One hundred and twenty-five patients undergoing dialysis were selected as subjects. The experimental group participants were identified as those having one or more VAT during the previous 13 months and the control group participants had no access thrombosis during the same period. Additional subgroup analysis included the presence of hypertension, diabetes, low-density lipoprotein levels, sex, and use of aspirin. RESULTS: No statistically significant difference was found in total homocysteine levels between the two groups (P = 0.27). No association was found between VAT and sex (P = 0.09), VAT and hypertension (P = 0.96), VAT and diabetes (P = 0.49), nor VAT and low-density lipoprotein level (P = 0.04). A lower rate of VAT was associated with aspirin intake (P = 0.04). CONCLUSION: This study did not demonstrate a relationship between total homocysteine concentrations and risk of VAT in patients with end-stage renal disease on hemodialysis. There were no significant differences in the number of VAT across additional variables of sex and previous morbidity. Aspirin intake was associated with a lower incidence of VAT.
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Authors | Chadi Saifan, Elie El-Charabaty, Suzanne El-Sayegh |
Journal | Vascular health and risk management
(Vasc Health Risk Manag)
Vol. 9
Pg. 361-4
( 2013)
ISSN: 1178-2048 [Electronic] New Zealand |
PMID | 23898227
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Fibrinolytic Agents
- Homocysteine
- Aspirin
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Topics |
- Aged
- Aspirin
(therapeutic use)
- Biomarkers
(blood)
- Chi-Square Distribution
- Diabetes Complications
(etiology)
- Female
- Fibrinolytic Agents
(therapeutic use)
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(blood, complications)
- Hypertension
(complications)
- Kidney Failure, Chronic
(blood, complications, therapy)
- Logistic Models
- Male
- Middle Aged
- Renal Dialysis
- Retrospective Studies
- Risk Factors
- Thrombosis
(blood, etiology, prevention & control)
- Up-Regulation
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