Abstract | BACKGROUND/AIM: Data on the clinicopathological features and prognostic impact of c-N-Methyl-N'-nitro-N-nitroso- guanidine HOS Transforming gene (c-MET) and hepatocyte growth factor (HGF) in hepatocellular carcinoma (HCC) are inconsistent. We assessed c-MET and HGF expression in 49 patients with early-stage HCC and correlated the results with disease characteristics and survival. MATERIALS AND METHODS: Expression of c-MET and HGF mRNA in tumor (T) and non- tumor (NT) tissues was assessed. Results were correlated with patient characteristics and overall and recurrence-free survival. RESULTS: Median relative tumor c-MET and HGF expressions were 3.23 (T/NT ratio 6.46) and 9.07 (T/NT ratio 0.77), respectively. c-MET and HGF were overexpressed in early-stage disease with favorable characteristics although there was no association with survival. CONCLUSION: Contrary to other studies, in our series increased tumor c-MET and HGF expressions were associated with favorable disease attributes but not with survival. The prognostic and therapeutic applications of this knowledge to HCC are under active investigation.
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Authors | Celina Su-Ping Ang, Mark Yipin Sun, David Fidel Huitzil-Melendez, Joanne Fu-Lou Chou, Marinela Capanu, William Jarnagin, Yuman Fong, Ronald Paul Dematteo, Michael D'Angelica, Peter Allen, Chin-Tung Chen, Eileen Mary O'Reilly, Martin Ross Weiser, Ghassan Khaled Abou-Alfa |
Journal | Anticancer research
(Anticancer Res)
Vol. 33
Issue 8
Pg. 3241-5
(Aug 2013)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23898085
(Publication Type: Journal Article)
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Chemical References |
- HGF protein, human
- RNA, Messenger
- Hepatocyte Growth Factor
- Proto-Oncogene Proteins c-met
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Topics |
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
(genetics, pathology)
- Demography
- Female
- Gene Expression Regulation, Neoplastic
- Hepatocyte Growth Factor
(genetics, metabolism)
- Humans
- Liver Neoplasms
(genetics, pathology)
- Male
- Middle Aged
- Proto-Oncogene Proteins c-met
(genetics, metabolism)
- RNA, Messenger
(genetics, metabolism)
- Survival Analysis
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