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c-MET and HGF mRNA expression in hepatocellular carcinoma: correlation with clinicopathological features and survival.

AbstractBACKGROUND/AIM:
Data on the clinicopathological features and prognostic impact of c-N-Methyl-N'-nitro-N-nitroso-guanidine HOS Transforming gene (c-MET) and hepatocyte growth factor (HGF) in hepatocellular carcinoma (HCC) are inconsistent. We assessed c-MET and HGF expression in 49 patients with early-stage HCC and correlated the results with disease characteristics and survival.
MATERIALS AND METHODS:
Expression of c-MET and HGF mRNA in tumor (T) and non-tumor (NT) tissues was assessed. Results were correlated with patient characteristics and overall and recurrence-free survival.
RESULTS:
Median relative tumor c-MET and HGF expressions were 3.23 (T/NT ratio 6.46) and 9.07 (T/NT ratio 0.77), respectively. c-MET and HGF were overexpressed in early-stage disease with favorable characteristics although there was no association with survival.
CONCLUSION:
Contrary to other studies, in our series increased tumor c-MET and HGF expressions were associated with favorable disease attributes but not with survival. The prognostic and therapeutic applications of this knowledge to HCC are under active investigation.
AuthorsCelina Su-Ping Ang, Mark Yipin Sun, David Fidel Huitzil-Melendez, Joanne Fu-Lou Chou, Marinela Capanu, William Jarnagin, Yuman Fong, Ronald Paul Dematteo, Michael D'Angelica, Peter Allen, Chin-Tung Chen, Eileen Mary O'Reilly, Martin Ross Weiser, Ghassan Khaled Abou-Alfa
JournalAnticancer research (Anticancer Res) Vol. 33 Issue 8 Pg. 3241-5 (Aug 2013) ISSN: 1791-7530 [Electronic] Greece
PMID23898085 (Publication Type: Journal Article)
Chemical References
  • HGF protein, human
  • RNA, Messenger
  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met
Topics
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular (genetics, pathology)
  • Demography
  • Female
  • Gene Expression Regulation, Neoplastic
  • Hepatocyte Growth Factor (genetics, metabolism)
  • Humans
  • Liver Neoplasms (genetics, pathology)
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins c-met (genetics, metabolism)
  • RNA, Messenger (genetics, metabolism)
  • Survival Analysis

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