Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis.

Abstract

PURPOSE:

The primary purpose of this study was to investigate the relationship between Pediatric Ulcerative Colitis Activity Index (PUCAI) and operative management. We also specifically evaluated those patients receiving tacrolimus for their disease.

METHODS:

A retrospective review (1/06-1/11) identified ulcerative colitis patients (≤21 years old) undergoing restorative proctocolectomy with rectal mucosectomy and ileal pouch-anal anastomosis. Main outcomes included pre-operative PUCAI, combined versus staged procedure, and postoperative complications. Patients receiving tacrolimus within 3 months of surgical intervention were identified. PUCAI at tacrolimus induction and medication side effects were also noted.

RESULTS:

Sixty patients were identified. Forty-two (70%) underwent combined and 18 (30%) had staged procedures. Pre-operative PUCAI was lower for combined versus staged patients (p = < 0.001). Furthermore, a higher pre-operative PUCAI strongly correlated with the likelihood of undergoing a staged procedure (p < 0.001). Forty-four patients (73%) received tacrolimus. Significant improvement in their PUCAI was noted from induction to pre-operative evaluation (p < 0.001). Minor and reversible side effects occurred in 46% of patients receiving tacrolimus, but complication rates were not significantly different.

CONCLUSIONS:

There is a very strong correlation between the PUCAI and the likelihood of undergoing a staged procedure. A significant improvement in PUCAI occurs following preoperative tacrolimus therapy.

• Authors: Fabienne L Gray, Christopher G Turner, David Zurakowski, Athos Bousvaros, Bradley C Linden, Robert C Shamberger, Craig W Lillehei
• Journal: Journal of pediatric surgery (J Pediatr Surg) Vol. 48 Issue 7 Pg. 1540-5 (Jul 2013) ISSN: 1531-5037 [Electronic] United States
• PMID: 23895969 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Immunosuppressive Agents
• Tacrolimus

Topics

• Adolescent
• Child
• Child, Preschool
• Colitis, Ulcerative (diagnosis, drug therapy, surgery)
• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Male
• Predictive Value of Tests
• Retrospective Studies
• Tacrolimus (therapeutic use)
• Young Adult