ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy.

Abstract

Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the proximity of dying cells and promotes their differentiation into mature DCs endowed with the capacity of presenting tumor-associated antigens.

• Authors: Yuting Ma, Sandy Adjemian, Heng Yang, João Paulo Portela Catani, Dalil Hannani, Isabelle Martins, Mickaël Michaud, Oliver Kepp, Abdul Qader Sukkurwala, Erika Vacchelli, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer
• Journal: Oncoimmunology (Oncoimmunology) Vol. 2 Issue 6 Pg. e24568 (Jun 01 2013) ISSN: 2162-4011 [Print] United States
• PMID: 23894718 (Publication Type: Journal Article)