Effects of clotrimazol on the acute necrotizing pancreatitis in rats.

Abstract

This study aims to investigate the influence of clotrimazol (CLTZ) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. Rats were divided into five groups as sham + saline, sham + CLTZ, sham + polyethylene glycol, ANP + saline, and ANP + CLTZ. ANP in rats was induced by glycodeoxycholic acid. The extent of acinar cell injury, mortality, systemic cardiorespiratory variables, functional capillary density (FCD), renal/hepatic functions, and changes in some enzyme markers for pancreatic and lung tissue were investigated during ANP in rats. The use of CLTZ after the induction of ANP resulted in a significant decrease in the mortality rate, pancreatic necrosis, and serum activity of amylase, alanine aminotransferase, interleukin-6, lactate dehydrogenase in bronchoalveolar lavage fluid, serum concentration of urea, and tissue activity of myeloperoxidase, and malondialdehyde in the pancreas and lung and a significant increase in concentrations of calcium, blood pressure, urine output, pO2, and FCD. This study showed that CLTZ demonstrated beneficial effect on the course of ANP in rats. Therefore, it may be used in the treatment of acute pancreatitis.

• Authors: Arif Burak Cekic, Etem Alhan, Arif Usta, Serdar Türkyılmaz, Birgül Vanizor Kural, Cengiz Erçin
• Journal: Inflammation (Inflammation) Vol. 36 Issue 6 Pg. 1576-83 (Dec 2013) ISSN: 1573-2576 [Electronic] United States
• PMID: 23892997 (Publication Type: Journal Article)

Chemical References

• 14-alpha Demethylase Inhibitors
• Interleukin-6
• Glycodeoxycholic Acid
• Malondialdehyde
• Urea
• L-Lactate Dehydrogenase
• Peroxidase
• Alanine Transaminase
• Amylases
• Clotrimazole
• Calcium

Topics

• 14-alpha Demethylase Inhibitors (therapeutic use)
• Alanine Transaminase (blood)
• Amylases (blood)
• Animals
• Blood Pressure (drug effects)
• Bronchoalveolar Lavage Fluid (chemistry)
• Calcium (blood)
• Clotrimazole (therapeutic use)
• Disease Models, Animal
• Glycodeoxycholic Acid
• Interleukin-6 (blood)
• L-Lactate Dehydrogenase (metabolism)
• Lung (metabolism)
• Male
• Malondialdehyde (metabolism)
• Pancreas (metabolism)
• Pancreatitis, Acute Necrotizing (chemically induced, drug therapy, mortality)
• Peroxidase (metabolism)
• Rats
• Rats, Sprague-Dawley
• Urea (blood)